DermaGen’s proprietary peptides originate from several classes of the human innate immune system. The portfolio includes peptides that are endogenous, end-modified, or modified internally of which some are described below.
End-modified linear AMPs
By a simple end-modification, the activity of this AMP type is enhanced to make it active against, e.g. S. aureus and Candida spp. Similar end-modifications of other AMP sequences have yielded several peptides with significant antimicrobial activity for use in different indications such as topical indications that need a high and consistent antimicrobial effect.
Endogenous helical AMPs
The bioactive properties of these peptides make them extremely suitable for indications characterized by infection and inflammation. These peptides may also promote cell growth, which directs the clinical use towards possible indications like burn wounds, wound infections and sepsis. Other helical AMPs based on a certain well-defined class of peptides comprise structures with defined low toxicity as well as broad antimicrobial activity.
Endogenous linear AMPs
This class of AMPs comprises interesting sequences. The most studied AMP from this class retains activity in complex environments.