Technology

References

Published articles

  1. Dermatan sulfate is released by proteinases of common pathogenic bacteria and inactivates antibacterial alpha-defensin. Schmidtchen A., Frick I.-M., Björck L. Mol Microbiol 2001; 39: 708.
  2. Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37. Schmidtchen A. Frick I.-M., Andersson E., Tapper H., Björck L. Mol Microbiol 2002; 46: 157.
  3. Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote adherence to host cells. Frick I.-M., Schmidtchen A,. Sjöbring, U. Eur J Biochem, 2003; 270: 2303.
  4. Antimicrobial activities of heparin-binding peptides. Andersson A., Rydengård V., Sonesson A., Mörgelin M., Björck L., Schmidtchen, A. Eur J Biochem, 2004, 271:1219.
  5. Activation of the complement system generates antibacterial peptides. Nordahl E., Rydengård V., Nyberg P., Nitsche D.P., Mörgelin M., Malmsten M., Björck L, Schmidtchen A. Proceedings of the National Academy of Sciences USA, 2004, 30:16879.
  6. Domain 5 of high molecular weight kininogen is antibacterial. Nordahl E., Rydengård V., Mörgelin M., Schmidtchen A. Journal of Biological Chemistry, 2005, 280:34832.
  7. Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluids. Baranska-Rybak W., Sonesson A., Nowicki R., Schmidtchen A. Journal of Antimicrobial Chemotherapy, 2006, 57:260.
  8. Bacterial killing by heparin-binding peptides from PRELP and thrombospondin. Malmsten M., Davoudi M., Schmidtchen A. Matrix Biology, 2006, Jul;25(5):294.
  9. Zinc potentiates the antibacterial effects of histidine-rich peptides against Enterococcus faecalis. Rydengård V., Nordahl E., Schmidtchen A. FEBS Journal, 2006, Jun;273(11):2399.
  10. The Contact System - A Novel Branch of Innate Immunity. Frick I.-M., Åkesson P., Herwald H., Mörgelin M., Malmsten M., Nägler D.K., Björck L. EMBO J. 2006, 25, 5569.
  11. Soft Drug Delivery Systems. Malmsten M. Soft Matter 2006, 2, 760.
  12. Effect of Peptide Length on the Interaction between (AKKARA)n and (ARKKAAKA)n Peptides and DOPC/DOPA Bilayers. Ringstad L., Schmidtchen A., Malmsten M. Langmuir 2006, 22, 5042.
  13. In silico identification and biological evaluation of antimicrobial peptides based on human cathelicidin LL-37. Sigurdardottir T., Andersson P., Davoudi M., Malmsten M., Schmidtchen A., Bodelsson M. Antimicrobial Agents Chemotherapy, 2006, 50: 2983.
  14. Composition Effect on Peptide Interaction with Lipids and Bacteria: Variants of C3a Peptide CNY21. Ringstad L., Andersson Nordahl E., Schmidtchen A., Malmsten M. Biophys J. 2007 Jan 1;92:87.
  15. Antifungal activity of C3a and C3a-derived peptides against Candida. Sonesson A., Ringstad L., Andersson Nordahl E., Malmsten M., Mörgelin M., Schmidtchen A. Biochim Biophys Acta. 2007;1768:346.
  16. Histidine-rich glycoprotein exerts antibacterial activity. Rydengård V., Olsson A. K., Mörgelin M., Schmidtchen A. FEBS Journal 2007 274:2 377.
  17. Preservation of antimicrobial properties of complement peptide C3a, from invertebrates to humans. Pasupuleti M., Walse B., Andersson Nordahl E., Mörgelin M., Malmsten M., Schmidtchen A. J Biol Chem. 2007;282:2520.
  18. Effects of topology, length, and charge on the activity of a kininogen-derived peptide on lipid membranes and bacteria. Ringstad L., Kacprzyk L., Schmidtchen A., Malmsten M. Biochim Biophys Acta. 2007, 1768, 715.
  19. Antimicrobial peptides derived from growth factors. Malmsten M., Davoudi M., Walse B., Rydengård V., Pasupuleti M., Mörgelin M., Schmidtchen, A.
    Growth Factors, 2007, 25: 60.
  20. Bactericidal and Hemolytic Properties of Mixed LL-37/Surfactant Systems. Reijmar K., Schmidtchen A., Malmsten M. J. Drug Delivery Sci. Technol., 2007.
  21. Antimicrobial activity of histidine-rich peptides is dependent of acidic conditions. Kacprzyk L., Rydengård V., Malmsten M., Schmidtchen A. Biochim Biophys Acta. 2007 Nov;1768(11):2667.
  22. Effect of Lipid Headgroup Composition on the Interaction between Melittin and Lipid Bilayers. Strömstedt A., Wessman P., Ringstad L., Edwards K., Malmsten M. J. Colloid Interface Sci. 2007, 311, 59.
  23. Antimicrobial C3a - Evolution, Biology, and Biophysics. Malmsten M., Schmidtchen A. Adv. Exp. Med. Biol. 2007, 598, 141.
  24. Phase Transformations in Self-Assembly Systems for Drug Delivery Applications. Malmsten M. J. Disp. Sci. Technol. 2007, 28, 63.
  25. An Electrochemical Study on the Interaction between Complement-Derived Peptides and DOPC Mono- and Bilayers. Ringstad L., Protopapa E., Lindholm-Sethson B., Schmidtchen A., Nelson A., Malmsten M. Langmuir 2008, 24, 208.
  26. Rational Design of Antimicrobial C3a Analogues with Enhanced Effects against Staphylococci Using an Integrated Structure and Function-Based Approach. Pasupuleti M., Walse B., Svensson B., Malmsten M., Schmidtchen A. Biochemistry. 2008, 47: 9057.
  27. Histidine-rich glycoprotein protects from systemic Candida infection. Rydengård V., Shannon O., Lundqvist K., Kacprzyk L., Chalupka A., Olsson A.K., Mörgelin M., Jahnen-Dechent W., Malmsten M., Schmidtchen A. PLoS Pathogens 2008, 4: e1000116.
  28. The Human CXC-Chemokine Granulocytes Chemotactic Protein 2 (GCP-2)/CXCL6 has Antibacterial Activity. Linge H.M., Collin M., Nordenfelt P., Mörgelin M., Malmsten M., Egesten A. Antimicrob. Agents Chemother. 2008 52, 2599-2607.
  29. Melittin-Lipid Bilayer Interactions and the Role of Chlesterol. Wessman P., Strömstedt A., Malmsten M., Edwards K. Biophys. J. 2008, 95, 4324.
  30. Interfacial Aspects in Drug Delivery. Malmsten M. In Encyclopedia of Surface and Colloid Science, Ed. P. Somasundaran, Taylor & Francis, New York, 2009.
  31. Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37. Strömstedt A.A., Pasupuleti M., Schmidtchen A., Malmsten M. Antimicrob Agents Chemother. 2009, 53:593.
  32. Microgels in Drug Delivery. Malmsten M. In Microgel Suspensions – Fundamentals and Applications. Eds. J. Mattsson, A. Fernandez-Nieves, H. Wyss, D.A. Weitz. Wiley-VCH Verlag GmbH&Co., New York, accepted for publication.

Submitted papers

  1. Boosting Antimicrobial Peptides by Hydrophobic Amino Acids. Schmidtchen, M. Pasupuleti, M. Mörgelin, M. Davoudi, J. Alenfall, A. Chalupka and M. MalmstenJ. Biol. Chem., submitted.
  2. End-Tagging of Ultra-Short Antimicrobial Peptides by W/F Stretches to Facilitate Bacterial Killing. M. Pasupuleti, A. Schmidtchen, A. Chalupka, L. Ringstad and M. Malmsten. PLoS One, submitted.
  3. Tryptophan End-Tagging of Antimicrobial Peptides for Increased Potency against Pseudomonas Aeruginosa. M. Pasupuleti, A. Chalupka, M. Mörgelin, A. Schmidtchen and M. Malmsten. Biochim. Biophys. Acta, submitted.
  4. Antimicrobial Activity of a C-Terminal Peptide of Human Extracellular Superoxide Dismutase. M. Pasupuleti, M. Davoudi, M. Malmsten, and A. Schmidtchen. BMC Res. Notes, submitted.
  5. Binding and Release of Consensus Peptides by Poly(Acrylic Acid) Microgels. H. Bysell, A. Schmidtchen and M. Malmsten. J. Colloid Interface Sci., submitted.
  6. Effects of Single Amino Acid Substitutions on Peptide Interaction with Lipid Membranes and Bacteria - Variants of GKE21, an Internal Sequence from Human LL-37. L. Ringstad, A. Schmidtchen, and M. Malmsten. Colloids Surf. A, submitted.